Second opinion (PHX 6.3) [RSABE / ABEL]
Thank you Helmut!
Detlew, need help!
Here is the covariance output from SAS on ln AUCt
Question, what does the residual "formulation Test" represent? Is it the residual attributed to both test and ref, while residual "formulation ref" is attributed to the ref (since it was given 2x)? which one would one use to compute the 90% geometric CI then?
Any hint on the stat approach?
Thanks
John
Detlew, need help!
Here is the covariance output from SAS on ln AUCt
Covariance Parameter Estimates
Cov Parm Subject Group Estimate
FA(1,1) subject 0.4427
FA(2,1) subject 0.4236
FA(2,2) subject 0.2481
Residual subject formulation Ref 0.05301
Residual subject formulation Test 0.02648
Question, what does the residual "formulation Test" represent? Is it the residual attributed to both test and ref, while residual "formulation ref" is attributed to the ref (since it was given 2x)? which one would one use to compute the 90% geometric CI then?
❝ IMHO, since a partial replicate according to FDA’s model is always (!) overspecified there is no guarantee that the LME-engines will converge. Don’t blame SAS and PHX; they warn us… Stupid design. If you want to have only three periods maybe it is better to run a fully replicated design (TRT|RTR) in the future.
Any hint on the stat approach?
Thanks
John
Complete thread:
- FDA's HVD SAS Code from Progesterone Guidance jag009 2013-04-22 16:39
- Proc MIXED vs. Proc GLM Helmut 2013-04-22 17:47
- Proc MIXED vs. Proc GLM jag009 2013-04-22 20:33
- SAS vs. PHX Helmut 2013-04-22 22:10
- SAS vs. PHX Shuanghe 2013-04-23 11:45
- SAS vs. SAS d_labes 2013-04-23 16:50
- SAS vs. SAS vs. Phoenix Helmut 2019-11-12 13:01
- SAS vs. SAS d_labes 2013-04-23 16:50
- SAS vs. PHX jag009 2013-04-23 15:56
- SAS Warning (Note) on Proc Mixed jag009 2013-04-23 17:07
- Nut Job.. jag009 2013-04-30 21:09
- Second opinion (PHX 6.3) Helmut 2013-05-01 16:21
- Second opinion (PHX 6.3)jag009 2013-05-01 17:16
- Second opinion (PHX 6.3) ElMaestro 2013-05-01 18:48
- In praise of a full replicate Helmut 2013-05-01 19:16
- Third opinion d_labes 2013-05-02 12:00
- Compound Symmetry Helmut 2013-05-02 14:41
- Compound Symmetry - SASian (1) d_labes 2013-05-02 16:26
- Variance=0 Helmut 2013-05-03 16:07
- Compound Symmetry - SASian (1) d_labes 2013-05-02 16:26
- Compound Symmetry Helmut 2013-05-02 14:41
- Second opinion (PHX 6.3)jag009 2013-05-01 17:16
- Second opinion (PHX 6.3) Helmut 2013-05-01 16:21
- Nut Job.. jag009 2013-04-30 21:09
- SAS Warning (Note) on Proc Mixed jag009 2013-04-23 17:07
- SAS vs. PHX Shuanghe 2013-04-23 11:45
- SAS vs. PHX Helmut 2013-04-22 22:10
- Proc MIXED vs. Proc GLM jag009 2013-04-22 20:33
- Proc MIXED vs. Proc GLM Helmut 2013-04-22 17:47