Bioequivalence and Bioavailability Forum

Proc MIXED vs. Proc GLM [RSABE / ABEL]

posted by jag009  – NJ, 2013-04-22 22:33 (4015 d 02:58 ago) – Posting: # 10464
Views: 22,379

Hi Helmut,

Can you try this and let me know? Yes there are missing datapoints. The other 2 parameters worked out fine. I ran data from another study and everything worked as well. Only this dataset is giving me the finger. The difference is the missing values as other datasets had values for all subjects. Maybe the missing data is messing things up?

Data columns are Subject Period Sequence Formulation PK-parameter

My SAS SCABE for this parameter is

Theta    Bound y    (S2wr)    (sWR)   (T/R) Pt Est  95% Upper Crit
0.79669   -0.22198  0.41135  0.64137    89.8994     -0.18423

I ran Unscaled Avg BE (Progesterone guidance SAS code)

T/R Ratio     90% CI
101.021    80.7739 - 126.343



Sequence 1=ABB, 2=BAB, 3=BBA

1 3 BBA A 31.432
2 1 ABB A 23.746
4 1 ABB A 41.258
5 3 BBA A 24.887
6 2 BAB A 237.003
7 3 BBA A 35.132
8 1 ABB A 22.399
9 2 BAB A 77.187
10 2 BAB A 180.386
11 3 BBA A 40.623
12 1 ABB A 15.382
14 2 BAB A -
15 3 BBA A 75.768
17 1 ABB A 15.219
18 2 BAB A 136.554
19 1 ABB A 53.966
20 2 BAB A 18.509
21 3 BBA A 24.439
23 2 BAB A 23.710
25 2 BAB A 16.264
26 3 BBA A 41.160
27 1 ABB A 63.364
28 3 BBA A 46.344
29 1 ABB A 66.059
30 2 BAB A 2.539
31 3 BBA A -
32 1 ABB A 34.002
33 2 BAB A 61.070
34 3 BBA A 149.674
35 2 BAB A 26.440
36 1 ABB A 54.400
37 2 BAB A 39.185
38 3 BBA A 201.983
39 1 ABB A 17.831
40 3 BBA A 85.293
1 1 BBA B 40.705
1 2 BBA B 68.864
2 2 ABB B 13.020
2 3 ABB B 36.121
4 2 ABB B 102.646
4 3 ABB B 54.459
5 1 BBA B 9.396
5 2 BBA B 22.999
6 1 BAB B 309.754
6 3 BAB B 163.058
7 1 BBA B 41.710
7 2 BBA B 44.472
8 2 ABB B 2.915
8 3 ABB B -
9 1 BAB B 88.910
9 3 BAB B 109.897
10 1 BAB B 373.070
10 3 BAB B 529.088
11 1 BBA B 74.469
11 2 BBA B 80.379
12 2 ABB B 26.124
12 3 ABB B 18.094
14 1 BAB B 2.280
14 3 BAB B -
15 1 BBA B 99.409
15 2 BBA B 134.023
17 2 ABB B -
17 3 ABB B 3.694
18 1 BAB B 49.218
18 3 BAB B 42.806
19 2 ABB B 61.764
19 3 ABB B 47.537
20 1 BAB B 74.644
20 3 BAB B 36.181
21 1 BBA B 47.737
21 2 BBA B 30.634
23 1 BAB B 11.766
23 3 BAB B 14.121
25 1 BAB B 29.943
25 3 BAB B 20.244
26 1 BBA B 109.626
26 2 BBA B 80.252
27 2 ABB B 33.349
27 3 ABB B 124.874
28 1 BBA B 29.083
28 2 BBA B 23.024
29 2 ABB B 34.671
29 3 ABB B 23.049
30 1 BAB B 2.782
30 3 BAB B 2.249
31 1 BBA B 57.630
31 2 BBA B -
32 2 ABB B 24.816
32 3 ABB B 39.266
33 1 BAB B 68.419
33 3 BAB B 85.845
34 1 BBA B 51.760
34 2 BBA B 54.845
35 1 BAB B 30.751
35 3 BAB B 2.921
36 2 ABB B 70.271
36 3 ABB B 38.989
37 1 BAB B 114.890
37 3 BAB B 54.372
38 1 BBA B 98.310
38 2 BBA B 147.839
39 2 ABB B 534.900
39 3 ABB B 16.465
40 1 BBA B 176.916
40 2 BBA B 105.915

Thanks
John

Complete thread:

• FDA's HVD SAS Code from Progesterone Guidance jag009 2013-04-22 16:39 
  • Proc MIXED vs. Proc GLM Helmut 2013-04-22 17:47
    • Proc MIXED vs. Proc GLMjag009 2013-04-22 20:33
      • SAS vs. PHX Helmut 2013-04-22 22:10
        • SAS vs. PHX Shuanghe 2013-04-23 11:45
          • SAS vs. SAS d_labes 2013-04-23 16:50
            • SAS vs. SAS vs. Phoenix Helmut 2019-11-12 13:01
        • SAS vs. PHX jag009 2013-04-23 15:56
          • SAS Warning (Note) on Proc Mixed jag009 2013-04-23 17:07
            • Nut Job.. jag009 2013-04-30 21:09
              • Second opinion (PHX 6.3) Helmut 2013-05-01 16:21
                • Second opinion (PHX 6.3) jag009 2013-05-01 17:16
                  • Second opinion (PHX 6.3) ElMaestro 2013-05-01 18:48
                  • In praise of a full replicate Helmut 2013-05-01 19:16
                  • Third opinion d_labes 2013-05-02 12:00
                    • Compound Symmetry Helmut 2013-05-02 14:41
                      • Compound Symmetry - SASian (1) d_labes 2013-05-02 16:26
                        • Variance=0 Helmut 2013-05-03 16:07