IVIVC / Mapping [Dissolution / BCS / IVIVC]

posted by Helmut Homepage – Vienna, Austria, 2007-09-01 16:49 (5638 d 06:09 ago) – Posting: # 1046
Views: 35,093

Dear HMY!

❝ Anyone know how to calculate the plasma profile using in vitro dissolution profile and IVIVC?

Yes. :cool:

❝ i.e. in vivo absorption profile -> plasma profile

This is the concept of ‘Mapping’. You should have all tools given previously in this thread handy.
Once you have an IVIVC established, it’s trivial to calculate in vivo dissolution and therefore predict the plasma profile.
What is your question?

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
 Admin contact
22,485 posts in 4,710 threads, 1,603 registered users;
14 visitors (0 registered, 14 guests [including 9 identified bots]).
Forum time: 21:59 CET (Europe/Vienna)

The difference between a surrogate and a true endpoint
is like the difference between a cheque and cash.
You can get the cheque earlier but then,
of course, it might bounce.    Stephen Senn

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz