FDA's HVD SAS Code from Progesterone Guidance [RSABE / ABEL]
Hi everyone,
I am getting some strange results using the FDA Progesterone Scaled Average Bioequivalence SAS Code → The portion to compute the Unscaled Average 90% C.I.
Should the Test/Reference Ratio from the Scaled Average BE computation be similar (if not the same) as the ratio computed from the above Unscaled Average BE code?
Thanks
John
Edit: Category changed. [Helmut]
I am getting some strange results using the FDA Progesterone Scaled Average Bioequivalence SAS Code → The portion to compute the Unscaled Average 90% C.I.
PROC MIXED
data=pk;
CLASSES SEQ SUBJ PER TRT;
MODEL LAUCT = SEQ PER TRT/ DDFM=SATTERTH;
RANDOM TRT/TYPE=FA0(2) SUB=SUBJ G;
REPEATED/GRP=TRT SUB=SUJ;
ESTIMATE 'T vs. R' TRT 1 -1/CL ALPHA=0.1;
ods output Estimates=unsc1;
title1 'unscaled BE 90% CI - guidance version';
title2 'AUCt';
run; data unsc1;
set unsc1;
unscabe_lower=exp(lower);
unscabe_upper=exp(upper);
run;
Should the Test/Reference Ratio from the Scaled Average BE computation be similar (if not the same) as the ratio computed from the above Unscaled Average BE code?
Thanks
John
Edit: Category changed. [Helmut]
Complete thread:
- FDA's HVD SAS Code from Progesterone Guidancejag009 2013-04-22 16:39
- Proc MIXED vs. Proc GLM Helmut 2013-04-22 17:47
- Proc MIXED vs. Proc GLM jag009 2013-04-22 20:33
- SAS vs. PHX Helmut 2013-04-22 22:10
- SAS vs. PHX Shuanghe 2013-04-23 11:45
- SAS vs. SAS d_labes 2013-04-23 16:50
- SAS vs. SAS vs. Phoenix Helmut 2019-11-12 13:01
- SAS vs. SAS d_labes 2013-04-23 16:50
- SAS vs. PHX jag009 2013-04-23 15:56
- SAS Warning (Note) on Proc Mixed jag009 2013-04-23 17:07
- Nut Job.. jag009 2013-04-30 21:09
- Second opinion (PHX 6.3) Helmut 2013-05-01 16:21
- Second opinion (PHX 6.3) jag009 2013-05-01 17:16
- Second opinion (PHX 6.3) ElMaestro 2013-05-01 18:48
- In praise of a full replicate Helmut 2013-05-01 19:16
- Third opinion d_labes 2013-05-02 12:00
- Compound Symmetry Helmut 2013-05-02 14:41
- Compound Symmetry - SASian (1) d_labes 2013-05-02 16:26
- Variance=0 Helmut 2013-05-03 16:07
- Compound Symmetry - SASian (1) d_labes 2013-05-02 16:26
- Compound Symmetry Helmut 2013-05-02 14:41
- Second opinion (PHX 6.3) jag009 2013-05-01 17:16
- Second opinion (PHX 6.3) Helmut 2013-05-01 16:21
- Nut Job.. jag009 2013-04-30 21:09
- SAS Warning (Note) on Proc Mixed jag009 2013-04-23 17:07
- SAS vs. PHX Shuanghe 2013-04-23 11:45
- SAS vs. PHX Helmut 2013-04-22 22:10
- Proc MIXED vs. Proc GLM jag009 2013-04-22 20:33
- Proc MIXED vs. Proc GLM Helmut 2013-04-22 17:47