Bioequivalence and Bioavailability Forum

Proc Mixed: parallel groups with different variabilities [Design Issues]

posted by jag009  – NJ, 2013-04-08 22:22 (4458 d 15:29 ago) – Posting: # 10374
Views: 8,014

Hi Detlew,

❝ ❝ Personally I don't see what additional variability(ies) one can extract from a parallel study other than inter-subject CV ...

❝

❝ If this should be read total CV, correct.

❝ But the two groups of subjects (under Test or Reference treatment) would allow the separate estimation of CV(tot.)_T and CV(tot.)_R (or s2_T, s2_R in the log domain). And this should be reflected in the overall model.

I see what you mean Yes there should be a intersubject CV for T and R separately since we have two pools of subjects given either T or R.

Thanks
John

Complete thread:

• drugs of long half life Ken Peh 2013-03-31 06:43 [Design Issues] 
  • drugs of long half life jag009 2013-04-02 15:17
    • drugs of long half life Helmut 2013-04-02 15:34
      • drugs of long half life jag009 2013-04-02 16:01
        • drugs of long half life Helmut 2013-04-02 16:40
          • parallel FDA d_labes 2013-04-04 08:33
            • parallel FDA jag009 2013-04-05 18:01
            • parallel FDA jag009 2013-04-05 21:10
              • random repeated parallel FDA d_labes 2013-04-08 08:29
                • Proc Mixed: random repeated parallel FDA jag009 2013-04-08 15:36
                  • Proc Mixed: parallel groups with different variabilities d_labes 2013-04-08 16:41
                    • Proc Mixed: parallel groups with different variabilitiesjag009 2013-04-08 20:22
    • drugs of long half life Ken Peh 2013-04-04 15:03
      • drugs of long half life jag009 2013-04-05 17:45