Bioequivalence and Bioavailability Forum • parallel FDA

parallel FDA [Design Issues]

posted by jag009 – NJ, 2013-04-05 23:10 (4405 d 05:19 ago) – Posting: # 10363
Views: 7,784

Hi Detlew,

❝ Dear Helmut, dear John,

❝

❝ ❝ ❝ Question, the anova model (GLM) will only contain 1 factor, correct?

❝ ❝

❝ ❝ Yep – I would suggest treatment. :-D

❝

❝ A one-way ANOVA (GLM) evaluation will not fit the FDA guideline (see this post long ago).

❝ It is equivalent to the assumption of equal variances.

❝

❝ If you only have 2 groups you can revert to the Welch t-test.

❝ Or you must code something with Proc MIXED (if you speak SASenese :cool: )

Something like this? :-D

Proc mixed data=s1;
class subject trt;
model lcmax=trt / ddfm=satterth;
lsmeans trt /pdiff cl alpha=.1;
estimate 'T vs R' trt 1 -1/ cl alpha=0.1;

John

Complete thread:

drugs of long half life Ken Peh 2013-03-31 06:43 [Design Issues]
- drugs of long half life jag009 2013-04-02 15:17
  - drugs of long half life Helmut 2013-04-02 15:34
    - drugs of long half life jag009 2013-04-02 16:01
      - drugs of long half life Helmut 2013-04-02 16:40
        
        parallel FDA d_labes 2013-04-04 08:33
        
        parallel FDA jag009 2013-04-05 18:01
        parallel FDAjag009 2013-04-05 21:10
        
        random repeated parallel FDA d_labes 2013-04-08 08:29
        
        Proc Mixed: random repeated parallel FDA jag009 2013-04-08 15:36
        
        Proc Mixed: parallel groups with different variabilities d_labes 2013-04-08 16:41
        
        Proc Mixed: parallel groups with different variabilities jag009 2013-04-08 20:22
  - drugs of long half life Ken Peh 2013-04-04 15:03
    - drugs of long half life jag009 2013-04-05 17:45