Bioequivalence and Bioavailability Forum • Two tests, one ref, replicate for ref for possiblescaling.

Two tests, one ref, replicate for ref for possiblescaling. [Design Issues]

posted by Ken Peh – Malaysia, 2013-04-05 22:23 (4821 d 13:47 ago) – Posting: # 10361
Views: 7,797

Dear ElMaestro,

❝ If I get you right, then Test(Caps)-Test(Tabs)-Ref-Ref and (a subset of) permutations thereof will work.

Yes. Do you mean similar to fully replicate design (2x2x4)? So, the design is as follows :-

Sequence 1 R - T(cap) - T(tab) - R
Sequence 2 T(cap)- R - R - T(tab)

Are the statistics and computations same as that of fully replicate design?

Thank you.

Regards,
Ken

Complete thread:

Highly variable drugs of different dosage forms Ken Peh 2013-04-05 14:00 [Design Issues]
- Highly variable drugs of different dosage forms jag009 2013-04-05 15:46
  - Highly variable drugs of different dosage forms Ken Peh 2013-04-05 20:26
- Two tests, one ref, replicate for ref for possiblescaling. ElMaestro 2013-04-05 17:37
  - Two tests, one ref, replicate for ref for possiblescaling.Ken Peh 2013-04-05 20:23
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