Bioequivalence and Bioavailability Forum

Highly variable drugs of different dosage forms [Design Issues]

posted by Ken Peh – Malaysia, 2013-04-05 16:00 (4820 d 12:29 ago) – Posting: # 10350
Views: 10,117

Dear All,

We can run a 3-way crossover study comparing a test product in different dosage forms (capsule and tablet) and a reference product.

For highly variable drug, we need to carry out replicate design, either partial or full replicate. How to fit one reference product and one test product in different dosage forms into replicate design ? Any idea ?

Thank you.

Regards,
Ken

Complete thread:

• Highly variable drugs of different dosage formsKen Peh 2013-04-05 14:00 [Design Issues] 
  • Highly variable drugs of different dosage forms jag009 2013-04-05 15:46
    • Highly variable drugs of different dosage forms Ken Peh 2013-04-05 20:26
  • Two tests, one ref, replicate for ref for possiblescaling. ElMaestro 2013-04-05 17:37
    • Two tests, one ref, replicate for ref for possiblescaling. Ken Peh 2013-04-05 20:23
      • Hush hush ElMaestro 2013-04-06 00:28
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          • Hush hush baby ElMaestro 2013-04-08 12:23
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      • T1-T2-R-R d_labes 2013-04-08 09:10