Bioequivalence and Bioavailability Forum

N=24, 48 [RSABE / ABEL]

posted by d_labes  – Berlin, Germany, 2013-03-18 09:11 (4054 d 02:06 ago) – Posting: # 10216
Views: 20,148
(edited by d_labes on 2013-03-18 09:52)

Dear Helmut!

❝ No explicit design written down in the code. That means default -> "2x3x3". n=48 if I remember correctly.

Must correct me: N=24 in the calculations above. nsims=1E6.

N=48 comes here:
    CV      GMR pBE_ABEL     GMR2 pBE_RSABE
 0.200 1.250000 0.050071 1.250000  0.050197
 0.225 1.250000 0.050103 1.250000  0.050458
 0.250 1.250000 0.050896 1.250000  0.055809
 0.275 1.250000 0.057014 1.250000  0.084654
 0.300 1.250000 0.076539 1.250000  0.147126
 0.302 1.251782 0.075132 1.301734  0.045037
 0.325 1.272352 0.066421 1.326887  0.044747
 0.350 1.294853 0.063700 1.354484  0.040058
 0.375 1.317485 0.061786 1.382326  0.033091
 0.400 1.340231 0.058847 1.410391  0.026019
 0.425 1.363072 0.054528 1.438658  0.019674
 0.450 1.385991 0.048974 1.467104  0.014709
 0.475 1.408971 0.042496 1.495709  0.010821
 0.500 1.431997 0.035153 1.524452  0.008119
 0.525 1.431997 0.041243 1.553312  0.006059
 0.550 1.431997 0.045210 1.582270  0.004553
 0.575 1.431997 0.047477 1.611308  0.003430
 0.600 1.431997 0.048748 1.640406  0.002631
 0.625 1.431997 0.049389 1.669548  0.002035
 0.650 1.431997 0.049721 1.698717  0.001592
 0.675 1.431997 0.049877 1.727897  0.001291
 0.700 1.431997 0.049954 1.757073  0.001048
 0.725 1.431997 0.049987 1.786230  0.000879
 0.750 1.431997 0.049998 1.815356  0.000727
 0.775 1.431997 0.050014 1.844438  0.000621
 0.800 1.431997 0.050007 1.873464  0.000538

Complete thread:

• ‘alpha’ of scaled ABE? d_labes 2013-03-15 15:56 [RSABE / ABEL] 
  • ‘alpha’ of scaled ABE? Helmut 2013-03-15 17:27
    • ’alpha’ of scaled ABE: design d_labes 2013-03-16 20:10
      • N=24, 48d_labes 2013-03-18 08:11
        • adaptive design without adjustment martin 2013-03-25 20:47
          • α adjustment? Helmut 2013-03-26 15:21
            • iteratively adjusted alpha martin 2013-03-26 16:19
              • throw away our sample size tables? Helmut 2013-03-26 18:02
                • if real martin 2013-03-26 19:44
                  • regulators don’t care? Helmut 2013-03-26 21:18
                • adjusting α Helmut 2013-08-11 16:19
              • target α in sim’s? Helmut 2013-03-27 15:38
                • target α in sim’s? martin 2013-03-27 16:36
                  • If it is real: results Helmut 2013-03-28 23:20
                • having alpha martin 2013-03-28 15:08
                  • fixed swr Helmut 2013-03-28 23:34
                    • fixed swr martin 2013-03-29 15:07
                      • Yes but no but yes but no but… Helmut 2013-03-29 16:10