‘alpha’ of scaled ABE? [RSABE / ABEL]

posted by Helmut Homepage – Vienna, Austria, 2013-03-15 16:27 (2981 d 02:22 ago) – Posting: # 10203
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Dear Detlew!

» A rather natural choice IMHO would be to calculate the power at the border(s) of the widened BE acceptance limits.


» GMR=1.25 if CV<=0.3 or GMR=exp(0.8925742*CV2se(CV)) if CV>0.3 for the FDA RSABE
» GMR=1.25 if CV<=0.3 or GMR=exp(0.7601283*CV2se(CV)) if CV>0.3 for the EMA scABEL and cap on if CV>0.5


I would prefer a GMR of 0.80 since PowerTOST employs simulations – remember the “rounding thread”? ;-)


Which designs / sample sizes have you used? I’m struggling reproducing your numbers.

» Interesting! At least for me :yes:.

For me as well. I will ask the two Lászlós and maybe Panos Macheras.

Dif-tor heh smusma 🖖
Helmut Schütz

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