ratio = difference of logs! [Regulatives / Guidelines]

posted by Helmut Homepage – Vienna, Austria, 2013-03-11 01:17 (2870 d 07:37 ago) – Posting: # 10181
Views: 17,270

Dear Chirag,

» […] does this apply to the untransformed or Ln transformed data
»
» The ratios were fine with the Ln transformed data.

Raw data! You need the ln-transformed data only in the BE-statistics. You would have to calculate the difference of logs and backtransform to get % covered. Example:

AUCt 375, AUC 500, covered: 100×375/500=75%.
lnAUCt 5.9269, lnAUC 6.2146, covered: 100×ℯ5.9269–6.2146=75%.

A ratio of logs (95.37%) is nonsense.

Dif-tor heh smusma 🖖
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Activity
 Admin contact
21,303 posts in 4,441 threads, 1,487 registered users;
online 14 (1 registered, 13 guests [including 7 identified bots]).
Forum time: Monday 08:54 CET (Europe/Vienna)

I believe there is no philosophical high-road in science,
with epistemological signposts. No, we are in a jungle
and find our way by trial and error,
building our road behind us as we proceed.    Max Born

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5