Sampling (optimization?) [Design Issues]
Dear Simon,
Thanks for your valuable inputs on sampling time point optimization. I have WinNonlin and always work around with modelling & simulation before designing sampling time points for BE studies.
I would like to know if there is any limit for VIF? I understand that lower is better [0.25 or 0.24 is better than 0.26]. But how much upper deviation from ideal value [0.26 in this example] is acceptable.
In the example posted above you mean to say that a VIF 0.29 [with 8 sampling time points] is acceptable [with respect to Cmax] as against a nominal VIF of 0.26 [which would be costly with 11 sampling time points]. If I still modify the time points [with the same 8 or still lower say 7 sampling time points] and get a VIF of 0.30 will it be acceptable.
What does Sqrt[VIF]_P_% mean. What is its significance?
Thanks,
IP.
Thanks for your valuable inputs on sampling time point optimization. I have WinNonlin and always work around with modelling & simulation before designing sampling time points for BE studies.
I would like to know if there is any limit for VIF? I understand that lower is better [0.25 or 0.24 is better than 0.26]. But how much upper deviation from ideal value [0.26 in this example] is acceptable.
In the example posted above you mean to say that a VIF 0.29 [with 8 sampling time points] is acceptable [with respect to Cmax] as against a nominal VIF of 0.26 [which would be costly with 11 sampling time points]. If I still modify the time points [with the same 8 or still lower say 7 sampling time points] and get a VIF of 0.30 will it be acceptable.
What does Sqrt[VIF]_P_% mean. What is its significance?
Thanks,
IP.
—
Thanks & Regards,
IP.
Thanks & Regards,
IP.
Complete thread:
- How to Define Sampling Interval eduardojmorales 2006-10-05 21:11 [Design Issues]
- How to Define Sampling Interval eduardojmorales 2006-10-05 23:16
- Soliloquy? H_Rotter 2006-10-06 13:27
- Soliloquy? eduardojmorales 2006-10-10 18:09
- Algorithm (geometric progression) Helmut 2006-10-07 21:48
- Algorithm (geometric progression) eduardojmorales 2006-10-10 18:23
- Algorithm (geometric progression) Helmut 2006-10-10 19:05
- Algorithm (geometric progression) intuitivepharma 2013-02-28 08:10
- Geometric progression in Excel Helmut 2013-02-28 13:56
- Sampling (optimization?) Helmut 2013-02-28 16:50
- Sampling (optimization?) intuitivepharma 2013-03-01 07:42
- Sampling (optimization?) SDavis 2013-03-07 10:40
- VIFs? Helmut 2013-03-07 15:50
- Sampling (optimization?)intuitivepharma 2013-03-08 12:39
- Sampling (optimization?) SDavis 2013-03-07 10:40
- Sampling (optimization?) intuitivepharma 2013-03-01 07:42
- Algorithm (geometric progression) eduardojmorales 2006-10-10 18:23
- Soliloquy? H_Rotter 2006-10-06 13:27
- How to Define Sampling Interval eduardojmorales 2006-10-05 23:16