Bioequivalence and Bioavailability Forum

CVinter < CVintra: happens sometimes… [General Sta­tis­tics]

posted by Helmut  – Vienna, Austria, 2013-03-01 17:12 (4858 d 02:29 ago) – Posting: # 10140
Views: 13,217

Hi Rana,

❝ In what cases we do observe an intersubject variability is less than intrasubject variability?

No idea. Happens in ~ <10% of studies. Note: You might have to switch to an all fixed-effects model in SAS and Phoenix/WinNonlin.

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P.S.: Top-level posts please to the entire group – not to a person (this is a Forum – not a Chat-room).

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Complete thread:

• Intra subject variability vs Inter subject variability rana 2013-03-01 13:20 [General Sta­tis­tics] 
  • CVinter < CVintra: happens sometimes…Helmut 2013-03-01 16:12
    • CVinter < CVintra: happens sometimes… ElMaestro 2013-03-01 20:51
      • CVinter < CVintra: happens sometimes… Helmut 2013-03-01 23:10
        • CVinter < CVintra or negative variance component? d_labes 2013-03-02 15:57
          • Sometimes both… Helmut 2013-03-02 18:46
        • Must be the optimizer for Mixed Effects Muddles ElMaestro 2013-03-02 22:22
          • Fixed Effects Muddleties d_labes 2013-03-05 12:57
            • Fixed Effects Muddleties ElMaestro 2013-03-05 13:06
            • Fixed Effects Muddleties Helmut 2013-03-05 15:53