Bioequivalence and Bioavailability Forum • Median tmax

Median tmax [Regulatives / Guidelines]

posted by Helmut – Vienna, Austria, 2013-02-19 21:28 (4863 d 20:41 ago) – Posting: # 10066
Views: 10,530

Hi John,

❝ Well I have 5 protocols here sitting on my desk from an Indian CRO. All of them use the word mean Tmax...

Ask them

Why they refer to the mean although the guidance states the median?
Mean t_max of what?
Whether they consider the mean an appropriate location statistic for a discrete distribution?

❝ I asked them and they said they have been using it with no issue.

Absence of evidence ≠ evidence of absence. Indians claim a lot.

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Complete thread:

FDA dropout guideline for Emesis jag009 2013-02-19 16:16 [Regulatives / Guidelines]
- Median tmax Helmut 2013-02-19 17:49
  - Median tmax jag009 2013-02-19 19:49
    - Median tmaxHelmut 2013-02-19 20:28
      - Median tmax jag009 2013-02-19 21:18
        
        Intellectual horsepower Helmut 2013-02-19 21:49
        
        Intellectual horsepower jag009 2013-02-19 22:45
        Intellectual horsepower jag009 2013-02-20 16:12
        
        Intellectual horsepower Helmut 2013-02-20 17:03
        
        Intellectual horsepower jag009 2013-02-20 22:05
      - Median tmax luvblooms 2013-02-20 05:03
        
        Sorry for the overgeneralization Helmut 2013-02-20 16:54
        
        overgeneralization ???? luvblooms 2013-02-21 05:23
        
        overgeneralization ???? Helmut 2013-02-21 12:17
        overgeneralization ???? jag009 2013-02-21 16:55
  - Median tmax intuitivepharma 2013-02-28 13:05
    - Median tmax from pilot studies Helmut 2013-02-28 14:02

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