Bioequivalence and Bioavailability Forum • Replicated cross over with fixed number of periods

Replicated cross over with fixed number of periods [Design Issues]

posted by martin – Austria, 2012-11-05 18:31 (4557 d 03:05 ago) – Posting: # 9504
Views: 6,240

Dear all!

I have a question regarding a special case of a replicated cross over trials where the number of periods is fixed in advance. Three products (one test and 2 reference products) will be investigated in n “subjects” where each “subject” will be treated 6 times (=fixed number of periods).

Using a kind of block randomization with block size = 3 will lead to the following sequences:

Sequence 1: A, B, C ; A, B, C
Sequence 2: A, C, B ; A, C, B
Sequence 3: B, A, C ; B, A, C
Sequence 4: B, C, A ; B, C, A
Sequence 5: C, A, B ; C, A, B
Sequence 6: C, B, A ; C, B, A

Can the study design be improved when using different sequences than the six mentioned above when the number of periods is fixed in advance?

Any ideas and suggestions are highly appreciated!!

best regards

martin

Complete thread:

Replicated cross over with fixed number of periodsmartin 2012-11-05 17:31 [Design Issues]
- Additional information martin 2012-11-06 11:50
  - Quick Q for my clarification ElMaestro 2012-11-06 12:09
    - Quick Q for my clarification martin 2012-11-06 12:29
      - 5 periods ElMaestro 2012-11-06 12:43
      - Latin Squares ↔ Williams’ designs Helmut 2012-11-06 14:07
        
        Latin Squares ↔ Williams’ designs Ben 2012-11-07 21:10
        
        Williams’ designs more reliable? d_labes 2012-11-08 08:29
        
        Williams’ designs more reliable? Ben 2012-11-09 18:20
        
        Williams’ designs more reliable? d_labes 2012-11-11 14:14
        
        Williams’ designs more reliable? Ben 2012-11-18 13:20
        
        Frequentists vs. Bayesians Helmut 2012-11-18 14:48
        
        Frequentists vs. Bayesians Ben 2012-11-18 15:28