Bioequivalence and Bioavailability Forum • Several group design with unequal washout

Several group design with unequal washout [Design Issues]

posted by sarawut – Thailand, 2012-05-08 14:36 (5147 d 16:27 ago) – Posting: # 8531
Views: 9,177

Dear all,

I have found a BE study in which the subjects were separated into 5 groups (I think by subject convenience, there were 5 starting dates) and the washout intervals were not identical (not the same in each subject but at least 7 days) (also I think by subject's convenience).

It is a standard 2x2x2 BE design for a total of 44 subjects with balanced arm.

Do you think it is acceptable if the test of group effect is not significant.
Also is it possible to test group effect in this study (5 groups)?

Any thought is welcome.

Sarawut

Complete thread:

Several group design with unequal washoutsarawut 2012-05-08 12:36 [Design Issues]
- Several group design with unequal washout Helmut 2012-05-08 13:40
  - Hidden Q? d_labes 2012-05-08 15:02
    - Q unveiled Helmut 2012-05-08 15:38
      - Q or not Q ? Ohlbe 2012-05-09 11:15
        
        "." ≠ "?" Helmut 2012-05-09 12:28
  - Several group design with unequal washout sarawut 2012-05-08 16:49
    - Several group design with unequal washout boonchai_l 2012-05-16 12:19
      - Thai FDA Helmut 2012-05-16 13:01
        
        Thai FDA boonchai_l 2012-05-16 13:37
        
        Thai FDA Helmut 2012-05-16 13:55
        
        Thai FDA boonchai_l 2012-05-16 19:02
        
        Thai FDA ElMaestro 2012-05-21 23:45
        
        Thai FDA boonchai_l 2012-05-21 12:05
- Several group design with unequal washout sarawut 2012-06-05 06:02