Bioequivalence and Bioavailability Forum

least square mean calculation [General Statistics]

posted by bvoggu – 2010-08-18 09:49 (5373 d 19:23 ago) – Posting: # 5801
Views: 10,469

Dear all
My name is Bharat kumar (Trainee in pharmacokinetics dept.)
In our company, calculations of least square mean were done according to SAS only.
But i want to learn all those manually in excel.

Up to my knowledge... LSM will be calculated by doing average of parameter of one treatment in period 1 and average of same in period 2, followed by dividing the sum of both averages by 2 (2 in case of two periods, right?).
My questions are:

While doing calculations with same formula, i am getting correct values for AUCt, Cmax but for AUCinf i am getting different values.
Anybody will help me about this issue???
what is the formula for calculation of standard error of difference?
Please suggest me a book especially for statistical part of PK?

—
Regards,
Bharat

Complete thread:

least square mean calculationbvoggu 2010-08-18 07:49 [General Statistics]
- least square mean calculation Helmut 2010-08-18 14:15
  - least square mean calculation bvoggu 2010-08-19 09:24
    - SE: SAS / PHX-WNL / manual Helmut 2010-08-19 12:36
      - Standard error d_labes 2010-08-19 16:18
        
        Standard error Helmut 2010-08-19 16:33
        Standard error bvoggu 2010-08-20 10:51
        
        Not with EXCEL d_labes 2010-08-20 14:57
- least square mean calculation ElMaestro 2010-08-18 14:46
  - least square mean calculation bvoggu 2010-08-20 07:41
    - LSMeans ElMaestro 2010-08-20 09:34

least square mean calculation [General Sta­tis­tics]

Complete thread:

least square mean calculation [General Statistics]