Bioequivalence and Bioavailability Forum • Pk parameter: Urine study (WinNonlin)

Pk parameter: Urine study (WinNonlin) [Software]

posted by AA – Ahmedabad, 2010-04-07 09:01 (5495 d 21:34 ago) – Posting: # 5028
Views: 22,472

Hi, All...

Can anyone clear my doubt regarding the urine study?

One of the pk parameters of urine study is:

Ae(0-t)-Total amount of drug excreted unchanged in the urine over the entire period of sample collection (0-t hours).

is calculation of Ae(0-t)=AURClast in WinNonlin?

Thanks in advance...

Edit: Category changed. Please give a (nick-)name in your profile/signature. Your initials carries ambiguity in some languages… [Helmut]

Complete thread:

Pk parameter: Urine study (WinNonlin)AA 2010-04-07 07:01 [Software]
- Ae-inf based on rate Helmut 2010-04-07 18:26
  - Ae-inf based on rate AA 2010-04-08 14:08
    - Amount_ Recovered = Ae(0-t) Helmut 2010-04-08 14:27
  - Already a PK-model? H_Rotter 2010-04-08 20:07
    - Already a PK-model? Helmut 2010-04-08 20:47
      - Dinosaurs solution. d_labes 2010-04-09 09:31
        
        Youngster's solution Helmut 2010-04-09 17:25
        
        Some youngsters may be very old d_labes 2010-04-12 09:39
  - Ae-inf based on rate SDavis 2010-04-09 13:10
    - Replicate design studies in Phoenix/WinNonlin Helmut 2010-04-09 17:47