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RegisterCanadian Guidance [Regulatives / Guidelines]
Dear all,
As per Canadian guidance the formula for Intra subject CV% is
Intra-subject CV = 100 × (MSResidual)0.5
But it is not matching with WinNonlin result.
WinNonlin is using Intra-subject CV = Sqrt(exp(MSE)-1)*100.
Plz explain these differences from guidance to software.
As per Canadian guidance the formula for Intra subject CV% is
Intra-subject CV = 100 × (MSResidual)0.5
But it is not matching with WinNonlin result.
WinNonlin is using Intra-subject CV = Sqrt(exp(MSE)-1)*100.
Plz explain these differences from guidance to software.
—
Rgds
Raveendranath
Rgds
Raveendranath
Complete thread:
- Canadian Guidancegraveendranath 2009-09-30 14:07 [Regulatives / Guidelines]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Avoid approximative formula! Helmut 2009-09-30 15:04
Ing. Helmut Schütz