Bioequivalence and Bioavailability Forum

Dear all,

I discovered a site where you can run R-packages in the browser (CRAN, Bioconductor). Useful when traveling. 

Here the link to yesterday’s release of PowerTOST. Navigate to the bottom

Try the PowerTOST package in your browser

and change

help(PowerTOST)

to

sampleN.TOST(CV = 0.3)

click

      Run (Ctrl-Enter)       

to get


+++++++++++ Equivalence test - TOST +++++++++++
            Sample size estimation
-----------------------------------------------
Study design:  2x2 crossover
log-transformed data (multiplicative model)

alpha = 0.05, target power = 0.8
BE margins = 0.8 ... 1.25
True ratio = 0.95,  CV = 0.3

Sample size (total)
 n     power
40   0.815845

The Man pages are available as well (e.g., the one of sampleN.TOST).

Note that there is a runtime limit of 10 seconds. Hence, demanding stuff like

scABEL.ad(CV = 0.3, n = 34, design = "2x2x4")

will not work.