Bioequivalence and Bioavailability Forum • Sample Size Calculation

Sample Size Calculation [Software]

posted by sasikumar – Tamilnadu, India, 2008-04-03 11:19 (6641 d 05:19 ago) – Posting: # 1755
Views: 36,618

Dear All,

Thanks for your previous prompt answer for CV calculation!

I used the following SAS Procedure for Sample Size Calculation and I hope that it would have been a right procdure for calculating power and sample size for BA/BE studies.

How to calculate manually while I am using log transformed data?
Please help me in this regard for manual calculation especially "meanratio" and "Lower and Upper bound" and "CV" or give me a practical example with formula or any material.

proc power;

 Twosamplemeans 

  test      = Equiv_ratio 

  dist      = lognormal

  meanratio = .1

  CV        = 1.05

  lower     = .80   /*I have doubt that how to fix lower and upper bound, I have doubt that  20% of reference mean of ln transformed or unlogtransformed*/

  upper     = 1.20

  alpha     = 0.01

  power     = .8 .9 

  total     = .; 

run;

Thanks in advance,

S.Sasikumar

Edit: Reformatted using BBCode 'code' [Helmut]

Complete thread:

Sample Size Calculationsasikumar 2008-04-03 09:19 [Software]
- Sample Size Calculation (SAS) Jaime_R 2008-04-03 13:13
- Sample Size Calculation d_labes 2008-04-23 11:54
  - Sample Size Calculation balakotu 2009-09-07 07:51
  - Sample Size Calculation yuvrajkatkar 2009-09-19 09:24
    - Paper, pencil, brain ;-) Helmut 2009-09-19 11:48
      - Paper, pencil, brain ;-) yuvrajkatkar 2009-09-21 15:10
        
        Paper, pencil, brain ;-) Helmut 2009-09-21 15:23
        Paper, pencil, brain ;-) Helmut 2009-09-21 18:33
        
        Paper, pencil, brain ;-) yuvrajkatkar 2009-09-22 16:09
        
        No paper, pencil, brain :-( Helmut 2009-09-22 18:22
        
        about your lectures yuvrajkatkar 2009-09-23 07:27
        
        About Trust Helmut 2009-09-23 13:50
        
        sample size calculation yuvrajkatkar 2009-10-01 13:33
        
        inter- / intra- / total variance Helmut 2009-10-01 13:52
        
        inter- / intra- / total variance yuvrajkatkar 2009-10-01 17:13
        
        Theta?! Helmut 2009-10-01 17:30
        
        sample size for parallel design yuvrajkatkar 2009-10-03 07:44
        
        Reference? Helmut 2009-10-03 13:46
        
        MSE obtain from Parallel study in WinNonlin yuvrajkatkar 2009-10-09 16:46
        
        Parallel study in WinNonlin Helmut 2009-10-10 10:51