Bioequivalence and Bioavailability Forum

Hi All,

Please clariffy my doubt regarding the analysis of a BE study with unequal sequences. For a 2 x 2 BE study of total 24 subjects with two sequences AB and BA.i.e, 12 subjects with sequence AB and 12 with sequence BA. But in the end of the study one subject in the sequence AB is dropped out.So 11 subjects with seq AB and 12 subjects with seq BA.

Is there any problem if I analyse this unbalanced data using a usual GLM procedure in SAS.? or go for a MIXED procedure in SAS?.

Any diffence in the output?

Regards

Matz