Bioequivalence and Bioavailability Forum • Reproducing Bear results in Phoenix

Reproducing Bear results in Phoenix [🇷 for BE/BA]

posted by mittyri – Russia, 2015-04-14 10:35 (3680 d 10:29 ago) – Posting: # 14681
Views: 31,916

Dear Yung-jin, Helmut and all,

Could you please guide me, I cannot reproduce the results from Bear demo sheet (SingleRep - full replicate design) in Phoenix.
I used the WNL reference template published on this forum.
For Bear the results are (lnCmax only for sake of brevity):

**************** Classical (Shortest) 90% C.I. for lnCmax ****************

        Point Estimate   CI90 lower   CI90 upper

Ratio          106.581       98.364      115.485

For Phoenix:

Source    Ratio_%Ref_  CI_90_Lower  CI_90_Upper

Method C  106.5814736   97.91422516 116.0159363

Method A  106.5814736  101.8775288  111.5026114

Method B  106.5814736  101.8775288  111.5026114

Exploring the dataset I've found that the sequences aren't common RTRT/TRTR, but RTTR/TRRT. Is it important for calculations?

Edit: Category changed. [Helmut]

—
Kind regards,
Mittyri

Thread locked

Complete thread:

Reproducing Bear results in Phoenixmittyri 2015-04-14 08:35 [🇷 for BE/BA]
- Bug in bear? Helmut 2015-04-14 14:07
  - Bug in bear? mittyri 2015-04-14 20:43
    - Bug in bear? Helmut 2015-04-15 02:17
  - use the same dataset? yjlee168 2015-04-20 10:13
- Bugs in bear with replicated demo data set? yjlee168 2015-04-15 09:38
- Bugs fixed in bear? yjlee168 2015-04-17 01:21
  - Bugs fixed in bear? Helmut 2015-04-17 14:25
    - Bugs fixed in bear? yjlee168 2015-04-17 18:50
      - Bugs fixed in bear? ElMaestro 2015-04-17 23:14
        
        lme() in bear yjlee168 2015-04-18 11:12
        
        lme() in bear ElMaestro 2015-04-18 11:28
        
        lme() in bear yjlee168 2015-04-18 12:02
        
        lme() in bear ElMaestro 2015-04-18 13:42
        
        Mean means Helmut 2015-04-18 14:08
        
        Mean means ElMaestro 2015-04-18 16:01
        
        Mean means Helmut 2015-04-19 00:59
        
        Mean means ElMaestro 2015-04-19 09:14
        
        LL and AIC Helmut 2015-04-19 11:08
        
        Confused ElMaestro 2015-04-19 11:42
        
        lsmeans for mixed model in R yjlee168 2015-04-19 23:36
        
        lsmeans() & lme() Helmut 2015-04-20 01:28
        
        lsmeans() & lme() yjlee168 2015-04-20 10:23
        lsmeans() & lme() ElMaestro 2015-04-20 10:35
        
        keep it simple! Helmut 2015-04-20 14:34
        
        keep it simple! ElMaestro 2015-04-20 15:39
        
        ML vs. REML Helmut 2015-04-20 16:35
        
        lme() with NA in R yjlee168 2015-04-19 23:44
      - Dataset Helmut 2015-04-18 13:30
        
        Dataset and lme() in bear yjlee168 2015-04-18 23:14