Interference Peak [Bioanalytics]

posted by Dr. Harish L. Rao – India, 2007-09-20 11:42 (6502 d 21:01 ago) – Posting: # 1096
Views: 6,094
(edited on 2007-09-20 11:56)

Dear Group Members,

During subject plasma sample analysis by LC/MS/MS, an extra peak (possibly due to metabolite) is observed which is not completely separated from the drug peak. But Method Validation was performed without the metabolite (as per OGD communication) & there was no interference peak during method validation. In such a situation, how should the analyst proceed with subject sample analysis?

Thanks & regards,
Dr. Harish L. Rao

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