Bioequivalence and Bioavailability Forum • power.inf()

power.inf() [BE/BA News]

posted by Helmut – Vienna, Austria, 2012-10-09 15:38 (4599 d 17:20 ago) – Posting: # 9355
Views: 11,986

Hi Detlew!

❝ Bug or a feature? :cool:

power.noninf(alpha=0.05, CV=0.298, margin=0.8, theta0=0.752, n=277)

# [1] 0.8010803

Feature! I didn’t realize that it’s possible to enter the house through the back door. :-D

Of course one can cheat as well (exchanging the limit with the ratio):

sampleN.noninf(alpha=0.05, CV=0.298, theta0=0.8, margin=0.752)

++++++++++++ Non-inferiority test +++++++++++++

            Sample size estimation

-----------------------------------------------

Study design:  2x2 crossover 

log-transformed data (multiplicative model)



alpha = 0.05, target power = 0.8

Non-inf. margin   = 0.752

Null (true) ratio = 0.8,  CV = 0.298



Sample size (total)

 n     power

278   0.802337

❝ Code from this thread (replacing the calls to internal PowerTOST functions to PowerTOST:::func_to_call, f.i. PowerTOST:::.design.no(design)) gives me 228

Hhm, can you be a little bit more specific (= for dummies like me)?

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Helmut Schütz

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Complete thread:

Bupropion ER Tablets Helmut 2012-10-05 15:59
- Bupropion ER Tablets jag009 2012-10-05 22:30
- results, wording ElMaestro 2012-10-05 23:35
  - Null hypothesis, PowerTOST/sampleN.inf() Helmut 2012-10-06 01:14
    - Null hypothesis, PowerTOST/sampleN.inf() ElMaestro 2012-10-07 13:11
    - power.inf() d_labes 2012-10-09 08:50
      - power.inf()Helmut 2012-10-09 13:38
        
        power.inf() d_labes 2012-10-09 15:58
        
        power.inf() Helmut 2012-10-09 19:51