Bioequivalence and Bioavailability Forum

❝ ❝ Is this a liquid formulation or semisolid formulation?

❝ The product where this topic was about is a liquid formulation, but in the

❝ mean time we have got the same problem with a semisolid formulation.

@aceto
It has been seem that pareben give good results with oil based formulations.
please ensure that you add presevative in the phase it has higher solubility and dissolve before making the final formulations.

It has been observed with Partitioning studies poor correlation between aqueous solubility and content of the preservatives in the aqueous phase of the emulsion. Incorporation of preservative into different microscopic structures of the emulsion is proposed as a reason for such effect. Higher concentration of antimicrobials or their combination may be required for efficient preservation of submicron emulsions.

gary