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Dear Dixit,
Lansoprazole is practically insoluble in water and extensively metabolized in liver. So, these factors may contribute to the high variability of this drug. Moreover, considering the solubility in water (0.97mg/L) and Log P value (1.9) this drug may be provisional classified as BCS class II, therefore the dissolution may be the key factor for its absorption. Generally, BCS class II drugs presents intrasubject variability (CVintra) higher than 30% in bioequivalence studies.
Additional comments will be welcome!
Daniel Rossi de Campos
Brazil
Lansoprazole is practically insoluble in water and extensively metabolized in liver. So, these factors may contribute to the high variability of this drug. Moreover, considering the solubility in water (0.97mg/L) and Log P value (1.9) this drug may be provisional classified as BCS class II, therefore the dissolution may be the key factor for its absorption. Generally, BCS class II drugs presents intrasubject variability (CVintra) higher than 30% in bioequivalence studies.
Additional comments will be welcome!
Daniel Rossi de Campos
Brazil
Complete thread:
- lansoprazole dixit 2009-02-10 05:57
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- lansoprazoledrcampos 2009-02-10 19:45
Ing. Helmut Schütz