Bioequivalence and Bioavailability Forum

ƒ of IV = 1 by definition, but… [Off Topic]

posted by Darborn – Taiwan, 2024-08-01 14:36 (309 d 13:05 ago) – Posting: # 24120
Views: 3,079

Actually it's not about a bioequivalence study or comparative BA study. It's about two intravenous formulations that one of them has longer half-life hence larger exposure. So I'm just bothered by which one of bioavailability fits this situation by definition, absolute or relative.

BTW, the guideline I refer to is FDA's "Bioavailability Studies Submitted in NDAs or INDs — General Considerations", page 3.

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Edit: Please follow the Forum’s Policy. Guidance linked. [Helmut]

Complete thread:

• A boring question about bioavailability? Darborn 2024-08-01 09:05 
  • ƒ of IV = 1 by definition, but… Helmut 2024-08-01 12:05
    • ƒ of IV = 1 by definition, but…Darborn 2024-08-01 12:36
      • IV: Different half-lives? Helmut 2024-08-01 13:43
        • IV: Different half-lives? Darborn 2024-08-02 02:39
          • IV: Liposome encapsuled drug, pegylated biologic? Helmut 2024-08-02 07:52
            • IV: Liposome encapsuled drug, pegylated biologic? Darborn 2024-08-06 05:15