Log in
RegisterRotten or not rotten ? [Off Topic]
Dear Nobody,
IMHO what would stink would be not to have any dog die during the preclinical studies. It would mean that either the maximum tolerated dose was not reached, or some data were masked.
According to information since published in the French press, these dogs received 100 mg/kg/day during 3 months (i.e. about 1500 mg/day). The subject who died got 50 mg/day over 5 days. None of the dogs had neurological problems of the same type as the 5 subjects.
❝ This stinks.
IMHO what would stink would be not to have any dog die during the preclinical studies. It would mean that either the maximum tolerated dose was not reached, or some data were masked.
According to information since published in the French press, these dogs received 100 mg/kg/day during 3 months (i.e. about 1500 mg/day). The subject who died got 50 mg/day over 5 days. None of the dogs had neurological problems of the same type as the 5 subjects.
—
Regards
Ohlbe
Regards
Ohlbe
Complete thread:
- Death in phase I cannabinoid? nobody 2016-01-15 16:49
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Death in phase I cannabinoid? Helmut 2016-01-15 17:25
- Death in phase I cannabinoid? nobody 2016-01-15 17:45
- Death in phase I cannabinoid? Helmut 2016-01-15 17:48
- Death in phase I cannabinoid? nobody 2016-01-15 18:02
- Structure Ohlbe 2016-01-18 13:42
- Structure nobody 2016-01-28 15:29
- Death in phase I cannabinoid? Helmut 2016-01-15 17:48
- Death in phase I cannabinoid? Ohlbe 2016-01-18 09:58
- Death in phase I cannabinoid? nobody 2016-01-18 15:07
- Death in phase I cannabinoid? nobody 2016-01-15 17:45
- Protocol Ohlbe 2016-01-22 17:18
- Protocol nobody 2016-01-23 18:37
- Protocol Ohlbe 2016-01-28 12:16
- Protocol ElMaestro 2016-01-28 15:07
- Protocol nobody 2016-01-28 15:40
- FIM / FIH Helmut 2016-01-28 17:10
- FIM / FIH nobody 2016-01-28 17:55
- There is something rotten in the state... nobody 2016-02-26 21:05
- Rotten or not rotten ?Ohlbe 2016-02-27 05:49
- Rotten or not rotten ? nobody 2016-02-27 10:56
- Rotten or not rotten ? Ohlbe 2016-02-27 14:00
- Rotten.. nobody 2016-04-25 17:21
- Blame game... nobody 2016-05-23 12:27
- FDA: "unique toxiciy" nobody 2016-08-15 16:38
- Blame game... nobody 2016-05-23 12:27
- Rotten.. nobody 2016-04-25 17:21
- Rotten or not rotten ? Ohlbe 2016-02-27 14:00
- Rotten or not rotten ? nobody 2016-02-27 10:56
- Rotten or not rotten ?Ohlbe 2016-02-27 05:49
- There is something rotten in the state... nobody 2016-02-26 21:05
- FIM / FIH nobody 2016-01-28 17:55
- FIM / FIH Helmut 2016-01-28 17:10
- Protocol nobody 2016-01-28 15:40
- Chronology - English version Ohlbe 2016-01-29 18:30
- Chronology - English version Helmut 2016-01-29 19:04
- Administrative inspection preliminary outcome Ohlbe 2016-02-04 23:30
- Chronology - English version Helmut 2016-01-29 19:04
- Protocol ElMaestro 2016-01-28 15:07
- Protocol Ohlbe 2016-01-28 12:16
- Protocol nobody 2016-01-23 18:37
- Re-consenting volunteers? ElMaestro 2016-06-21 16:42
- Re-consenting volunteers? Ohlbe 2016-06-22 05:06
- Re-consenting volunteers? nobody 2016-06-22 11:26
- Re-consenting volunteers? Ohlbe 2016-06-23 04:51
- Re-consenting volunteers? ElMaestro 2016-06-23 08:23
- Re-consenting volunteers? nobody 2016-06-23 10:36
- OT: strike d_labes 2016-06-23 11:31
- OT: strike Helmut 2016-06-23 13:01
- Re-consenting volunteers? ElMaestro 2016-06-23 08:23
- Re-consenting volunteers? Ohlbe 2016-06-23 04:51
- Re-consenting volunteers? nobody 2016-06-22 11:26
- Re-consenting volunteers? Ohlbe 2016-06-22 05:06
- Paper in the NEJM Ohlbe 2016-11-03 12:21
- Death in phase I cannabinoid? nobody 2017-06-09 10:01
- Death in phase I cannabinoid? Helmut 2016-01-15 17:25
Ing. Helmut Schütz