Bioequivalence and Bioavailability Forum

Dear Satya and HS,

There is indeed a lot of confusion. The old EU guideline (still on the EMEA website) uses "specificity". The definitions given in the annex are rather outdated:

Specific test procedure:
a procedure to measure quantitatively a chemical-physical parameter or functional group of one or even more but different analytes in the sample matrix;
for instance: titration of the carboxylic group of an acid, measure of the specific absorbance, immunoassay.

Selective test procedure:
a procedure to detect qualitatively the analyte in the presence of components which maybe expected to be present in the sample matrix;
for instance: chromatography, selective electrode.

By the way HS: unless I missed it this old EU guideline, still in force, is missing from your list of guidance documents. But I must admit it is really outdated (July 1990, if I'm not mistaken ?).

Regards
Ohlbe