Bioequivalence and Bioavailability Forum

Dear HS,

I am really on a high on this subject. Thanks we are really discussing technical aspects of BE not just guidelines (which I am bored of)!!!.
I really welcome your comments.

My answer was keeping in mind only BE studies. Nearly all most all the drugs undergo first-order elimination process. Under rare exception, even, drug delivery systems designed for zero order release shows first order elimination. I did not take into consideration when answering 5% rule, the zero-order processess and Michaelis-Menten type elimination. NCA is useful tool for typical single dose studies. At lower dose even drugs undergoing Michaelis-Menten type drugs show first order elimination profiles. Only at higher doses they show the dome shaped profile which is indicative of saturation. I agree with you.

Dr. Shiv

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Edit: Full quote removed. Please see this post! [HS]