Bioequivalence and Bioavailability Forum

Hi Ionsource!

❝ I'll do it as you say.

Caution: The last section in small print was meant as a joke! Get a candesartan reference standard. If you hydrolyze the ester (or even synthesize it – which is a 8-step procedure) you would have to show identity and purity. Of course that’s possible with the usual arsenal of physical chemistry (melting point, molecular mass, solubility, IR, UV ε, MS, NMR,…). That’s by far more expensive than buying a certified reference. If you are working with MS I would strongly suggest the one labeled on the core (²H₄ candesartan) rather than on the carboxylic radical (²H₅ candesartan).