Bioequivalence and Bioavailability Forum • Calibration Curve

Calibration Curve [Bioanalytics]

posted by Helmut – Vienna, Austria, 2012-01-21 13:35 (5267 d 13:29 ago) – Posting: # 7985
Views: 6,016

Dear Auditor!

❝ […] if we are taking duplicates (LLOQ & ULOQ) then we should consider both the duplicates (10 no. of samples) or mean of duplicates (LLOQ & ULOQ) for plotting?

Don’t plot means of duplicates (loss of visual information about their variability). Plot all data points you have used in the calibration, regardless whether you have used all n=10, dropped one (n=9), or two (n=8). Overlay the calibration curve based on the estimated slope and intercept.

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Complete thread:

Calibration Curve auditor 2012-01-20 11:15
- Duplicate LLOQ and ULOQ Ohlbe 2012-01-20 11:59
  - Duplicate LLOQ and ULOQ Helmut 2012-01-20 13:09
    - Duplicate LLOQ and ULOQ Ohlbe 2012-01-20 14:26
      - Duplicate LLOQ and ULOQ Helmut 2012-01-20 18:02
        
        Calibration Curve auditor 2012-01-21 05:45
        
        Calibration CurveHelmut 2012-01-21 12:35
        Calibration Curve Ohlbe 2012-01-21 13:44
        
        Calibration Curve Helmut 2012-01-22 21:48