Bioequivalence and Bioavailability Forum • Prasugrel and its metabolite

Prasugrel and its metabolite [Bioanalytics]

posted by Dr_Dan – Germany, 2010-12-14 10:39 (5670 d 10:11 ago) – Posting: # 6299
Views: 13,061

Dear all
R-138727 is highly unstable in plasma and must be derivatized immediately after blood sampling with 2-bromo-3'-methoxyacetophenone. The determination of R-138727 in plasma is described in several research articles, e.g. N. A. Farid et.al, Rapid Commun. Mass Spectrom. 2007, 21, 169 - 179. If you contact me directly I can offer you the derivatized trans-R-138727MP and the deuterated compound R-138727MP-d3. These compounds R-138727MP and R 138727MP d3 were used as standards to analyse the plasma samples of a comparative bioavailability study with two Prasugrel 10 mg formulations.
Do not hesitate to contact me.
Kind regards
Dan

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Kind regards and have a nice day
Dr_Dan

Complete thread:

Prasugrel and its metabolite ramesh_7779 2010-11-25 07:54
- Prasugrel and its metabolite Rajdeep 2010-11-25 08:21
  - Prasugrel and its metabolite ramesh_7779 2010-11-25 10:18
    - Prasugrel and its metabolite Dr_Dan 2010-11-25 16:59
      - Prasugrel and its metabolite ramesh_7779 2010-11-26 05:20
        
        Prasugrel and its metabolite Dr_Dan 2010-11-26 09:10
        
        Prasugrel and its metabolite ramesh_7779 2010-11-26 09:28
        Prasugrel and its metabolite sasikala 2010-12-04 15:17
        
        Prasugrel and its metabolite Dr_Dan 2010-12-06 08:51
        
        Prasugrel and its metabolite sasikala 2010-12-06 09:56
        
        Prasugrel and its metabolite muthu 2010-12-13 10:19
- Prasugrel and its metabolite marmikpatel_1981 2010-12-10 18:50
  - Prasugrel and its metaboliteDr_Dan 2010-12-14 09:39
    - Prasugrel and its metabolite marmikpatel_1981 2010-12-14 18:07