Bioequivalence and Bioavailability Forum • clopidogrel

clopidogrel [Bioanalytics]

posted by ioanam – Romania, 2010-08-10 12:42 (5794 d 08:17 ago) – Posting: # 5752
Views: 10,579

Dear all,

I need your help to clarify some results in a bioequivalence study for clopidogrel.

We have found values for plasma concentrations for clopidogrel more than 10 fold higher than those reported in literature.

The study was performed in healthy male and female subjects in standard fasting state.

Even clopidogrel is a highly variable drug, I can't explain these high values.

It is really possible to have peak concentrations of almost 20 pg/ml for clopidogrel? I don't think so. Am I right?

Thank you,
Ioanam

Complete thread:

clopidogrelioanam 2010-08-10 10:42
- clopidogrel Dr_Dan 2010-08-10 11:21
  - clopidogrel ioanam 2010-08-10 11:28
  - clopidogrel ioanam 2010-08-10 11:43
    - clopidogrel Ohlbe 2010-08-10 12:17
- clopidogrel ioanam 2010-08-10 14:13
  - clopidogrel Ohlbe 2010-08-10 14:59
    - clopidogrel ioanam 2010-08-10 15:17
      - clopidogrel Ohlbe 2010-08-10 16:12
        
        clopidogrel ioanam 2010-08-10 18:34
        
        clopidogrel Dr_Dan 2010-08-11 09:24
        
        clopidogrel ioanam 2010-08-11 11:08
        
        clopidogrel Ohlbe 2010-10-05 00:06