Bioequivalence and Bioavailability Forum • IMHO an open issue

IMHO an open issue [Bioanalytics]

posted by Helmut – Vienna, Austria, 2010-06-10 17:18 (5856 d 12:55 ago) – Posting: # 5496
Views: 4,796

Dear Shuja,

this topic was discussed at the EUFEPS/EBF-workshop last April in Brussels. Though it is possible to spike whole blood, we have only a method for plasma/serum… One of the suggestions was to spike whole blood (t=37 ℃) and study different conditions (room temperature or immediate cooling, increasing time intervals until centrifugation) and analyze samples with the method for plasma/serum. But: potential interconversion of metabolite(s) is not covered.
Interested in other opinions!

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Helmut Schütz

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Complete thread:

Blood stability testing during method validation shujak1 2010-06-10 14:53
- IMHO an open issueHelmut 2010-06-10 15:18
  - IMHO an open issue shujak1 2010-06-11 06:07
    - IMHO an open issue Helmut 2010-06-11 13:50
  - IMHO an open issue BPA 2010-06-11 10:21
    - IMHO an open issue Ohlbe 2010-06-11 10:44
      - IMHO an open issue BPA 2010-06-11 11:42
        
        IMHO an open issue Helmut 2010-06-11 13:41