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RegisterChange in analyte response [Bioanalytics]
Dear Ketan
I recommend to do an infusion test to determine the extent of the problem. Apparently, you have an ionization effect, therefore by infusing your drugs of interest along with the internal standards and injecting a QC sample versus a clinical sample, you will be able to see any ionization differences with time (maybe 30 minutes is sufficient). This will allow you to demonstrate the method is functioning properly (or not) without consuming a high volume of the clinical samples.
From past experience, I expect that modifying the gases will not solve your problem.
I recommend to do an infusion test to determine the extent of the problem. Apparently, you have an ionization effect, therefore by infusing your drugs of interest along with the internal standards and injecting a QC sample versus a clinical sample, you will be able to see any ionization differences with time (maybe 30 minutes is sufficient). This will allow you to demonstrate the method is functioning properly (or not) without consuming a high volume of the clinical samples.
From past experience, I expect that modifying the gases will not solve your problem.
Complete thread:
- Change in analyte response ketan 2010-05-17 07:44
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Change in analyte response Ohlbe 2010-05-17 10:25
- Change in analyte response ketan 2010-05-18 07:51
- Change in analyte response Ohlbe 2010-05-18 10:48
- Change in analyte response ketan 2010-05-18 12:06
- Change in analyte response Ohlbe 2010-05-18 14:29
- Change in analyte responsejchapdelaine 2010-05-18 15:01
- Change in analyte response Ohlbe 2010-05-18 14:29
- Change in analyte response ketan 2010-05-18 12:06
- Change in analyte response Ohlbe 2010-05-18 10:48
- Change in analyte response ketan 2010-05-18 07:51
- Change in analyte response Ohlbe 2010-05-17 10:25
Ing. Helmut Schütz