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RegisterChange of salt form [Bioanalytics]
Dear Members,
If clinical study has been performed with HCl salt of any analyte then can we prepare the calibration curve and quality control samples with sulfate form or free form of the same analyte ?
I mean if bioequivalence to be proved for metformin sulfate then can metformin hydrochloride be used for method validation ?
Regards,
bani
If clinical study has been performed with HCl salt of any analyte then can we prepare the calibration curve and quality control samples with sulfate form or free form of the same analyte ?
I mean if bioequivalence to be proved for metformin sulfate then can metformin hydrochloride be used for method validation ?
Regards,
bani
Complete thread:
- Change of salt formbabun 2009-08-21 14:28
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- only base/acid important Helmut 2009-08-21 15:19
- only base/acid important babun 2009-08-24 06:31
- only base/acid important Helmut 2009-08-21 15:19
Ing. Helmut Schütz