Bioequivalence and Bioavailability Forum

Good evening HS,

Thank you very much for the link and for taking the time to reply.

I feel I am in very good company when it comes to interchanging these terms:

"For a method to be considered acceptable, it is recommended that both the interbatch imprecision (%CV) and the accuracy, expressed as absolute mean bias (%RE) be ± 20% (25% at LLOQ and ULOQ)."

Then the very next phrase:

"As an additional constraint to control method error, it is recommended that the target total error (sum of the absolute value of the %RE [accuracy] and precision [%CV] be less than ± 30% [ ± 40% at the LLOQ and ULOQ])."

I guess we accept easily that the accuracy of a measurement of 100 mL is ± 1 mL (also absolute error), but when it is relative and it becomes 1%, then it doesn't sound that reassuring, so there comes "inaccuracy" to help. I may have to use only "%RE" to avoid comments from the two camps.

Thanks again!