Bioequivalence and Bioavailability Forum • OTC/Contraceptives: Interferences

OTC/Contraceptives: Interferences [Bioanalytics]

posted by Ohlbe – France, 2009-04-17 19:49 (6276 d 05:28 ago) – Posting: # 3558
Views: 7,314

Dear Helmut and Geokad,

In an ideal world, we would have all the time and money to do a great job. You would indeed test not only possible concomitant medications, but also their metabolites. And testing would not be limited to just checking for visible interferences, but also for possible matrix effects if using LC/MS/MS.

(yes, concomitant medications can cause ion suppression or enhancement, even just ibuprofen - see for instance

Leverence R., Avery M.J., Kavetskaia O, et al.
Signal suppression/enhancement in HPLC-ESI-MS/MS from concomitant medications
Biomed Chromatogr. 2007 Nov;21(11):1143-50

We don't live in an ideal world...

Regards
Ohlbe

Complete thread:

OTC and Contraceptives Geokad 2009-04-14 18:15
- OTC/Contraceptives: Interferences Helmut 2009-04-14 19:45
  - OTC/Contraceptives: InterferencesOhlbe 2009-04-17 17:49
    - OTC/Contraceptives: Interferences ElMaestro 2009-04-19 05:44
      - OTC/Contraceptives: Interferences Helmut 2009-04-19 14:36
        
        OTC/Contraceptives: Interferences ElMaestro 2009-04-21 01:20
        
        Selectivity in validation Helmut 2009-04-21 13:19
- OTC and Contraceptives NewInPK 2009-05-13 02:20
  - GLP vs. Good Scientific Practice Helmut 2009-05-16 16:49
    - GLP vs. Good Scientific Practice Ohlbe 2009-05-17 23:09
      - GLP vs. Good Scientific Practice Helmut 2009-05-17 23:42
        
        GLP and GCP Ohlbe 2009-05-18 10:22
        
        GLP and GCP Helmut 2009-05-18 11:31