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RegisterISTD variation: matrix effects ? [Bioanalytics]
Dear K.sathis & venkat,
I suppose that you tested 6 different sources of matrix. If you are using LC/MS/MS, you should pay a specific attention to matrix effects investigation, and if possible determine the matrix factor in the same 6 lots of matrix. This could be the explanation for such a variability, and then a source of trouble with your method.
Regards
Ohlbe
I suppose that you tested 6 different sources of matrix. If you are using LC/MS/MS, you should pay a specific attention to matrix effects investigation, and if possible determine the matrix factor in the same 6 lots of matrix. This could be the explanation for such a variability, and then a source of trouble with your method.
Regards
Ohlbe
Complete thread:
- ISTD variation in selectivity experiment satishkoya 2009-04-04 14:35
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- ISTD variation: matrix effects ?Ohlbe 2009-04-04 23:35
Ing. Helmut Schütz