Bioequivalence and Bioavailability Forum

Dear Eduardo!

❝ The HPLC analysis of one sample costs around $100 in El Salvador, Central

❝ America. The average BE study has 1200 samples. That means $120,000 in

❝ chemical analysis alone.

IMHO $100 for an HPLC sample is just ridiculous!
In Europe I would consider $20 - $40 (calculated on an exchange rate of EUR->USD of 1.25) per sample in a GLP-certified lab reasonable (depending on the method)...

❝ How does a BE lab charge $65,000 for the study of

❝ Carvedilol in Mass spectrophotometer?

Why not? This means $54/sample, which is not unrealistic; I know some MS-labs calculating prices as low as $45/sample (including method development and validation).
Maybe you should consider changing your CRO - or at least ship the samples for analysis to a more economically priced site...