Bioequivalence and Bioavailability Forum

Dear Geokad,

a few comments adding to Martin's.
Since you posted in the 'Bioanalytics' category, I guess you are rather interested in calibration, which in specialized statistical textbooks (e.g. Draper & Smith) is called 'inverse regression'. Apart from statistical tools (e.g., running an F-test on the 'full model' = quadratic vs the 'reduced model' = linear) mostly the distribution of residuals (no trend, no funnel shape, etc.) and accuracy/precision of back-calculated calibrators and QC-samples are used. Cave: although often seen, the coefficient of determination R² or the coefficient of correlation R are useless in model selection.