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RegisterReanalysis for PK Reason: Gone with the Wind [Bioanalytics]
Hi Dshah
I agree with you that these changes are very little. But you'd be amazed at how the difference between 826.125 and 826.375 is enough to make a study that failed (eg CI of T/R: 79.99 - 111.11) to pass (eg CI of T/R: 80.02 - 111.11).
Regards,
❝ time concentration 1 concentration 2 concentration 3 concentration 4
❝ AUC 826.125 826.375 826.625 826.75
❝ I believe that such small change in AUC can be considered non-significant. 
I agree with you that these changes are very little. But you'd be amazed at how the difference between 826.125 and 826.375 is enough to make a study that failed (eg CI of T/R: 79.99 - 111.11) to pass (eg CI of T/R: 80.02 - 111.11).
Regards,
—
Scopy
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Complete thread:
- Reanalysis for Pharmacokinetic Reason Obinoscopy 2020-07-16 14:30
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Reanalysis for PK Reason: Gone with the Wind Helmut 2020-07-16 15:10
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Ing. Helmut Schütz