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RegisterInterference from Deuterated IS [Bioanalytics]
Dear VKB2207,
Sure. It's called the intercept
Certainly not. It is taken into consideration when calculating the calibration curve parameters, unless you are forcing the intercept through 0 (which is not to be done in bioanalysis).
Not necessarily at high level of concentrations. Could indeed be problematic closer to the LLOQ.
❝ You can probably evaluate the % contribution from IS at RT of drug
Sure. It's called the intercept
❝ and then apply this factor in CC, QC nominal concentrations.
Certainly not. It is taken into consideration when calculating the calibration curve parameters, unless you are forcing the intercept through 0 (which is not to be done in bioanalysis).
❝ Hence measured concentrations would be inaccurate.
Not necessarily at high level of concentrations. Could indeed be problematic closer to the LLOQ.
—
Regards
Ohlbe
Regards
Ohlbe
Complete thread:
- Interference from Deuterated IS cakhatri 2019-01-10 07:20
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- Interference from Deuterated IS VKB2207 2019-01-10 20:48
- Interference from Deuterated ISOhlbe 2019-01-10 22:36
- Interference from Deuterated IS Ohlbe 2019-01-10 23:41
- Interference from Deuterated IS cakhatri 2019-01-11 09:28
- Interference from Deuterated IS ElMaestro 2019-01-11 09:49
- Interference from Deuterated IS VKB2207 2019-01-10 20:48
Ing. Helmut Schütz