Bioequivalence and Bioavailability Forum • Purpose of S:N?

Purpose of S:N? [Bioanalytics]

posted by Helmut – Vienna, Austria, 2018-11-08 10:46 (2779 d 16:04 ago) – Posting: # 19545
Views: 14,291

Hi ElMaestro,

❝ ❝ [...] two methods, A/P at the LLOQ 20/20%, S/N 10 or 15/15 5?

❝

❝ I don't follow this terminology, can you explain what you mean? My hindsight is 20/20.

Sorry, my wording was not clear. I meant: Both methods fullfil the required conditions for (in)accuracy and precision at the LLOQ (20%). The first one is right at the border (20/20) but with a nice S:N of 10. The second one is better in terms of A/C (15/15) despite a worse S:N of 5.
I guess most people would prefer #2. I don't see the purpose of S:N. IMHO, it is nice to know only.

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Complete thread:

Isn't it time for an open source chromatographic format ElMaestro 2018-11-04 21:54
- Isn't it time for an open source chromatographic format nobody 2018-11-05 09:00
  - and now that we are at it ElMaestro 2018-11-05 13:53
    - and now that we are at it nobody 2018-11-05 16:33
      - and now that we are at it ElMaestro 2018-11-05 18:19
    - Transparent ruler – like in the good ol’ days Helmut 2018-11-05 20:39
      - Transparent ruler – like in the good ol’ days Ohlbe 2018-11-05 22:14
        
        Transparent ruler – like in the good ol’ days ElMaestro 2018-11-05 22:43
        
        Slow down, you move too fast […] Feelin’ Groovy Helmut 2018-11-06 02:05
        
        Slow down, you move too fast […] Feelin’ Groovy nobody 2018-11-06 09:29
        
        Yes it went a little fast ElMaestro 2018-11-06 11:09
        
        Yes it went a little fast nobody 2018-11-06 12:05
        
        Yes it went a little fast ElMaestro 2018-11-06 12:10
        
        Yes it went a little fast Helmut 2018-11-07 16:09
        
        Yes it went a little fast ElMaestro 2018-11-07 16:22
        
        Yes it went a little fast nobody 2018-11-07 18:30
        Purpose of S:N?Helmut 2018-11-08 09:46
        
        Purpose of S:N? ElMaestro 2018-11-08 22:27
        
        Purpose of S:N? nobody 2018-11-09 10:06
        
        Purpose of S:N? Helmut 2018-11-09 11:34
        
        Purpose of S:N? nobody 2018-11-09 12:08
        
        Purpose of S:N? Helmut 2018-11-09 12:34
        
        Purpose of S:N? Helmut 2018-11-09 11:26
        
        Purpose of S:N? ElMaestro 2018-11-09 13:16
- Isn't it time for an open source chromatographic format paulhurleyuk 2018-11-05 16:27