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RegisterAn outlier? [Bioanalytics]
Hi Helmut and mittyri!
Please check now. Should work. THX to Moderator.
Looks like the value 1,479.61 ng / ml was taken from PAR of one big Indian pharmaceutical company. I’m not sure that it is average of different studies. BTW, what about seven and even eight significant digits (see PAR, pg 20)?
IMHO, that is actually the case. According to the article (Table 1), only 300 mg and 400 mg doses (not strengths) were included to the analysis. So looks like 60.8 ng / ml is an outlier due to extreme fast metabolizing?
❝ The link is not working. Can you check?
Please check now. Should work. THX to Moderator.
❝ Reporting concentrations to six significant digits even more. I assume that the “minimum arithmetic average Cmax” was calculated from different studies; each with a dose of 300 mg.
Looks like the value 1,479.61 ng / ml was taken from PAR of one big Indian pharmaceutical company. I’m not sure that it is average of different studies. BTW, what about seven and even eight significant digits (see PAR, pg 20)?
❝ In the analyzed studies, the minimum value of Cmax was 60.8 ng / ml,
IMHO, that is actually the case. According to the article (Table 1), only 300 mg and 400 mg doses (not strengths) were included to the analysis. So looks like 60.8 ng / ml is an outlier due to extreme fast metabolizing?
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Best regards
Beholder
Best regards
Beholder
Complete thread:
- Little thing which changes almost everything in EEU Beholder 2018-10-18 09:08
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- LLOQ ≤5% of expected or observed Cmax? Helmut 2018-10-18 12:28
- LLOQ ≤5% of average or minimal Cmax? Beholder 2018-10-18 13:59
- LLOQ ≤5% of individual Cmax-values Helmut 2018-10-18 18:20
- LLOQ ≤5% of individual Cmax-values mittyri 2018-10-18 19:50
- An outlier?Beholder 2018-10-19 09:43
- LLOQ ≤5% of individual Cmax-values mittyri 2018-10-18 19:50
- LLOQ ≤5% of individual Cmax-values Helmut 2018-10-18 18:20
- LLOQ ≤5% of average or minimal Cmax? Beholder 2018-10-18 13:59
- LLOQ ≤5% of expected or observed Cmax? Helmut 2018-10-18 12:28
Ing. Helmut Schütz