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Registerrecoveries more than 100% [Bioanalytics]
Hi everyone!
The % recovery was 107.80%, 112.65% and 105.92% for the low quality control (LQC) and middle quality controls (MQC2 and MQC1), respectively. Whereas % recovery for higher quality control (HQC) was 98.25%.
The % recovery was determined by comparing the mean peak area of 6 replicates of extracted quality control samples at High, Middle and Low concentrations against respective mean peak area of 6 replicates of un-extracted quality control samples at High, Middle and Low concentrations. Internal standard used was deuterated.
Kindly confirm recoveries markedly higher than 100% for LQC, MQC2 and MQC1 are acceptable as per USFDA guidelines?? Also specify reason for higher recoveries.
The % recovery was 107.80%, 112.65% and 105.92% for the low quality control (LQC) and middle quality controls (MQC2 and MQC1), respectively. Whereas % recovery for higher quality control (HQC) was 98.25%.
The % recovery was determined by comparing the mean peak area of 6 replicates of extracted quality control samples at High, Middle and Low concentrations against respective mean peak area of 6 replicates of un-extracted quality control samples at High, Middle and Low concentrations. Internal standard used was deuterated.
Kindly confirm recoveries markedly higher than 100% for LQC, MQC2 and MQC1 are acceptable as per USFDA guidelines?? Also specify reason for higher recoveries.
Complete thread:
- recoveries more than 100%deepakpangavhane 2018-09-03 08:28
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- recoveries more than 100% Ohlbe 2018-09-03 19:21
- recoveries more than 100% Ladi 2018-09-04 03:51
- recoveries more than 100% Kintan Patel 2018-11-29 11:48
- Origin of figures ? Ohlbe 2018-11-30 18:23
- Origin of figures ? Kintan Patel 2018-12-05 10:04
- Origin of figures ? Ohlbe 2018-12-05 10:30
- Origin of figures ? Kintan Patel 2018-12-05 10:04
- Origin of figures ? Ohlbe 2018-11-30 18:23
- recoveries more than 100% Kintan Patel 2018-11-29 11:48
Ing. Helmut Schütz