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RegisterBA/BE study - internal standard response variability [Bioanalytics]
Dear Members,
In BA/BE study bio-analysis, is high internal standard response variability is a cause for LC-MS data batch rejection? (for example more than 20% of the unknown samples showing more than ±50% difference etc..)
General practice is only one scenario is considered for IS variation (±50% difference from the mean), is there any other scenario to be considered?
Trend analysis for Internal standard area response? Please comment.
Thanks & regards,
Avinash Jain M V
In BA/BE study bio-analysis, is high internal standard response variability is a cause for LC-MS data batch rejection? (for example more than 20% of the unknown samples showing more than ±50% difference etc..)
General practice is only one scenario is considered for IS variation (±50% difference from the mean), is there any other scenario to be considered?
Trend analysis for Internal standard area response? Please comment.
Thanks & regards,
Avinash Jain M V
Complete thread:
- BA/BE study - internal standard response variabilityavinash 2018-07-11 06:44
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- BA/BE study - internal standard response variability ElMaestro 2018-07-11 08:14
- BA/BE study - internal standard response variability Ohlbe 2018-07-12 00:24
Ing. Helmut Schütz