Bioequivalence and Bioavailability Forum

I would not put tooooo much effort into stuff like this, 'cause you want change anything in practice, if you are not FDA+EMA and some other "key opinion leaders" in one person

If you want to think some real weird stuff, try to wrap your head around the concept of "LLOQ". THERE are very strange things going on. Fortunately under normal circumstances you have only few samples in this gray-area of reality.